MersV1, Main, Exploration, bibRecord, 001D29

Blocking of exchange proteins directly activated by cAMP leads to reduced replication of Middle East respiratory syndrome coronavirus.

Identifieur interne : 001D29 ( Main/Exploration ); précédent : 001D28; suivant : 001D30

Blocking of exchange proteins directly activated by cAMP leads to reduced replication of Middle East respiratory syndrome coronavirus.

Auteurs : Xinrong Tao [États-Unis] ; Feng Mei ; Anurodh Agrawal ; Clarence J. Peters ; Thomas G. Ksiazek ; Xiaodong Cheng ; Chien-Te K. Tseng

Source :

Journal of virology [ 1098-5514 ] ; 2014.

RBID : pubmed:24453361

Descripteurs français

KwdFr :
- AMP cyclique (métabolisme), Animaux, Coronavirus (), Coronavirus (physiologie), Facteurs d'échange de nucléotides guanyliques (antagonistes et inhibiteurs), Facteurs d'échange de nucléotides guanyliques (génétique), Humains, Interactions hôte-pathogène, Lignée cellulaire, Réplication virale (), Techniques de knock-down de gènes.
MESH :
- antagonistes et inhibiteurs : Facteurs d'échange de nucléotides guanyliques.
- génétique : Facteurs d'échange de nucléotides guanyliques.
- métabolisme : AMP cyclique.
- physiologie : Coronavirus.
- Animaux, Coronavirus, Humains, Interactions hôte-pathogène, Lignée cellulaire, Réplication virale, Techniques de knock-down de gènes.

English descriptors

KwdEn :
- Animals, Cell Line, Chlorocebus aethiops, Coronavirus (drug effects), Coronavirus (physiology), Cyclic AMP (metabolism), Gene Knockdown Techniques, Guanine Nucleotide Exchange Factors (antagonists & inhibitors), Guanine Nucleotide Exchange Factors (genetics), Host-Pathogen Interactions, Humans, Virus Replication (drug effects).
MESH :
- chemical , antagonists & inhibitors : Guanine Nucleotide Exchange Factors.
- chemical , genetics : Guanine Nucleotide Exchange Factors.
- chemical , metabolism : Cyclic AMP.
- drug effects : Coronavirus, Virus Replication.
- physiology : Coronavirus.
- Animals, Cell Line, Chlorocebus aethiops, Gene Knockdown Techniques, Host-Pathogen Interactions, Humans.

Abstract

The outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infections and diseases represents a potential threat for worldwide spread and requires development of effective therapeutic strategies. In this study, we revealed a novel positive function of an exchange protein directly activated by cyclic AMP 1 (cAMP-1; Epac-1) on MERS-CoV replication. Specifically, we have shown that Epac-specific inhibitor treatment or silencing Epac-1 gene expression rendered cells resistant to viral infection. We believe Epac-1 inhibitors deserve further study as potential therapeutic agents for MERS-CoV infection.

DOI: 10.1128/JVI.03001-13
PubMed: 24453361

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">The outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infections and diseases represents a potential threat for worldwide spread and requires development of effective therapeutic strategies. In this study, we revealed a novel positive function of an exchange protein directly activated by cyclic AMP 1 (cAMP-1; Epac-1) on MERS-CoV replication. Specifically, we have shown that Epac-specific inhibitor treatment or silencing Epac-1 gene expression rendered cells resistant to viral infection. We believe Epac-1 inhibitors deserve further study as potential therapeutic agents for MERS-CoV infection. </div>
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Serveur d'exploration MERS

Blocking of exchange proteins directly activated by cAMP leads to reduced replication of Middle East respiratory syndrome coronavirus.

Blocking of exchange proteins directly activated by cAMP leads to reduced replication of Middle East respiratory syndrome coronavirus.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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